Difference between mycobacterium tuberculosis &mycobacterium leprae

 

Difference between mycobacterium tuberculosis &mycobacterium leprae
 

Characters

Mycobacterium tuberculosis

Mycobacterium leprae

Gram Staining

Week Gram Positive

Week Gram Positive

Shape

Rod shape bacilli

Rod shape bacilli

Endospores

Absent

Absent

Capsule

Absent

Absent

Motility

Non-Motile

Non-Motile

Respiration

Aerobic respiration

Microaerophilic respiration

Optimum Temperature

37 °C

27 °C to 30 °C

Optimum pH

5.4 – 6.5

7.0

Incubation Period

2 to 6 Weeks

5 years.

Habitat

Found in water and soil.

Found in air, water and soil.

Respiration

Aerobic respiration

Microaerophilic respiration

Symotoms

l Cough

· Thick, stiff or dry skin

 

l Weight loss

· Painless ulcers on the soles of feet

l Coughing up blood or mucus

· Painless swelling or lumps on the face or earlobes

Acid Fast Staining

Red colour Acid fast bacilli

 

Red colour Acid fast bacilli

 

Motility Test

Non-motile

Non-Motile

Culture medium

Lowenstein Jensen (LJ) Medium-brown,

granular colonies

Animal cultute- Foot pads of mice (slow growing pathogen)

 

Catalase test -

Negative

No

Oxidase test

Negative

No

Urease test

Positive

No

Amidase test

Positive

No

Peroxidase test

Positive

No

Antibiotics

Isoniazid (INH)

Rifampicin

Ethambutol

Dapsone

Pyrazinamide

Clofazimine

 

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